Treatment patterns and clinical outcomes in acute myeloid leukemia patients who are not eligible for intensive induction chemotherapy: A real-world study from Latin-America

Palabras clave: acute myeloid leukemia, real-world, treatment outcome, antimetabolites, antineoplastic, Latin America.

Resumen

Introduction. There is a knowledge gap concerning patients with acute myeloid leukemia (AML) who are not eligible for intensive induction chemotherapy; this, together with a recent increase in the incidence in Latin America, encloses a need. Through real-world evidence, we describe and compare the results of the different treatment strategies within this context. Methodology. This is a longitudinal, descriptive, retrospective study of a cohort of Latin American patients with AML not eligible for intensive induction chemotherapy, treated with low-intensity chemotherapy or with the best supportive care alone between January 1, 2015, to December 31, 2018. Results. Of a total of 125 patients (median age 74.8 years), the majority received low-intensity chemotherapy (78.4%). The median time in months of overall survival (9.2), progression-free survival (4.8), and time to treatment failure (3.8) were longer in patients receiving hypomethylating agents. Additionally, better results were observed with low-intensity chemotherapy (complete response 11.2% and stable disease 17.3%) compared to the best supportive care alone. Conclusion. We deliver a real-world standpoint of Latin American patients with AML who are not eligible for intensive induction chemotherapy. Our findings pave the first steps of the way to describe, understand, and support informed decision-making processes in our region.

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Biografía del autor/a

Kenny Mauricio Gálvez-Cárdenas, Hospital Pablo Tobón Uribe

Médico, Especialista en Medicina Interna, Especialista en Hematología, Hospital Pablo Tobón Uribe. Medellín, Colombia.

Leonardo José Enciso-Olivera, Instituto Nacional de Cancerología

Médico, Especialista en Hematología, Instituto Nacional de Cancerología. Bogotá, Colombia.

César Augusto Samanez-Figari, AUNA-Oncosalud

Médico, Especialista en Hematología, AUNA-Oncosalud. Lima, Perú.

Shirley Quintana-Truyenque, Instituto Nacional de Enfermedades Neoplásicas, INEN

Médica, Especialista en Oncología, Instituto Nacional de Enfermedades Neoplásicas, INEN. Lima, Perú.

Benito Arturo Castillo-Ríos, Instituto Oncológico de Panamá

Médico, Especialista en Hematología, Departamento Oncológico, Instituto Oncológico de Panamá. Ciudad de Panamá, Panamá.

Guillermo Enrique Quintero-Vega, Fundación Santa Fe de Bogotá

Médico, Especialista en Hematología, Fundación Santa Fe de Bogotá. Bogotá, Colombia.

Elizabeth Arrieta-López, Fundación Valle del Lili

Médica, Especialista en Hematología, Departamento de Hematología, Fundación Valle del Lili. Cali, Colombia.

Alexis Javier Pinto-Gómez, Hospitalario Dr. Arnulfo Arias Madrid, Centro Oncológico de Panamá, Hospital Santa Fe

Médico, Especialista en Hematología, Servicio de Hematología, Complejo Hospitalario Dr. Arnulfo Arias Madrid (CH-DrAAM), Centro Oncológico de Panamá (COPSA), Hospital Santa Fe. Ciudad de Panamá, Panamá.

Sandra Aruachan-Vesga, Clínica IMAT Oncomédica

Médica, Clínica IMAT Oncomédica. Montería, Colombia.

María Isabel Durán-Sánchez, AbbVie S.A.S

Médica, Especialista en Epidemiología, MSc en Ciencias Biológicas, AbbVie S.A.S. Bogotá, Colombia.

Germán Espino-Lopéz, Centro Hemato-Oncológico Panamá

Médico, Especialista en Hematología, Centro Hemato-Oncológico Panamá (CHOP). Ciudad de Panamá, Panamá.

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Cómo citar
1.
Gálvez-Cárdenas KM, Enciso-Olivera LJ, Samanez-Figari CA, Quintana-Truyenque S, Castillo-Ríos BA, Quintero-Vega GE, Arrieta-López E, Pinto-Gómez AJ, Aruachan-Vesga S, Durán-Sánchez MI, Espino-Lopéz G. Treatment patterns and clinical outcomes in acute myeloid leukemia patients who are not eligible for intensive induction chemotherapy: A real-world study from Latin-America. Med. Lab. [Internet]. 21 de septiembre de 2023 [citado 23 de mayo de 2024];27(4):315-32. Disponible en: https://medicinaylaboratoriocom.biteca.online/index.php/myl/article/view/683
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2023-09-21
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